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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SAMHD1
All Species:
29.7
Human Site:
S295
Identified Species:
54.44
UniProt:
Q9Y3Z3
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y3Z3
NP_056289.2
626
72201
S295
K
G
R
P
E
N
K
S
F
L
Y
E
I
V
S
Chimpanzee
Pan troglodytes
XP_514624
382
43769
C80
I
T
G
A
L
L
P
C
L
D
E
S
R
F
E
Rhesus Macaque
Macaca mulatta
XP_001097562
728
83194
S397
K
G
R
P
E
R
K
S
F
L
Y
E
I
V
S
Dog
Lupus familis
XP_542986
665
76981
S333
K
G
R
P
K
E
K
S
F
L
Y
E
I
V
A
Cat
Felis silvestris
Mouse
Mus musculus
Q60710
627
72632
S296
K
G
R
P
A
T
K
S
F
L
Y
E
I
V
S
Rat
Rattus norvegicus
XP_230789
677
77635
S351
K
G
R
P
A
K
K
S
F
L
Y
E
I
V
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJL9
614
70202
S286
R
G
R
P
K
E
K
S
F
L
Y
E
I
V
A
Frog
Xenopus laevis
Q6INN8
632
72730
S300
R
G
R
T
E
E
K
S
F
L
Y
E
I
V
A
Zebra Danio
Brachydanio rerio
Q502K2
622
71649
S275
K
G
R
P
V
E
K
S
F
L
Y
E
V
V
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09374
587
66474
Y261
H
D
V
D
K
M
D
Y
L
L
R
D
S
K
A
Sea Urchin
Strong. purpuratus
XP_784786
594
68895
R269
E
G
R
G
R
E
K
R
F
L
Y
E
I
V
A
Poplar Tree
Populus trichocarpa
XP_002312899
477
54770
K175
V
D
S
E
M
M
R
K
V
K
E
M
I
L
A
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_568580
473
54655
K171
D
I
D
A
Q
M
L
K
R
V
K
D
M
I
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.9
79.5
73.5
N.A.
73.3
65.8
N.A.
N.A.
60
61.8
60.8
N.A.
N.A.
N.A.
22.5
46.8
Protein Similarity:
100
60.2
82.4
83.6
N.A.
83.2
76.2
N.A.
N.A.
74.9
75.3
74.1
N.A.
N.A.
N.A.
40.8
64.2
P-Site Identity:
100
0
93.3
80
N.A.
86.6
80
N.A.
N.A.
73.3
73.3
73.3
N.A.
N.A.
N.A.
6.6
60
P-Site Similarity:
100
0
93.3
93.3
N.A.
86.6
86.6
N.A.
N.A.
93.3
86.6
86.6
N.A.
N.A.
N.A.
26.6
73.3
Percent
Protein Identity:
28.2
N.A.
N.A.
30.5
N.A.
N.A.
Protein Similarity:
45
N.A.
N.A.
47.2
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
16
16
0
0
0
0
0
0
0
0
0
62
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
8
16
8
8
0
0
8
0
0
8
0
16
0
0
0
% D
% Glu:
8
0
0
8
24
39
0
0
0
0
16
70
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
70
0
0
0
0
8
0
% F
% Gly:
0
70
8
8
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
8
0
0
0
0
0
0
0
0
0
0
70
8
0
% I
% Lys:
47
0
0
0
24
8
70
16
0
8
8
0
0
8
0
% K
% Leu:
0
0
0
0
8
8
8
0
16
77
0
0
0
8
8
% L
% Met:
0
0
0
0
8
24
0
0
0
0
0
8
8
0
0
% M
% Asn:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
54
0
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
16
0
70
0
8
8
8
8
8
0
8
0
8
0
0
% R
% Ser:
0
0
8
0
0
0
0
62
0
0
0
8
8
0
24
% S
% Thr:
0
8
0
8
0
8
0
0
0
0
0
0
0
0
0
% T
% Val:
8
0
8
0
8
0
0
0
8
8
0
0
8
70
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
0
0
70
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _